Example:
Is ivermectin safe/effective in treating or preventing COVID?
The screenshot below shows PICO terms. I pick just the most important terms, highlighted in yellow below, to run a test (scoping) search.
Example: here is my proposed SR topic:
Efficacy and safety of ivermectin in treating/preventing COVID-19.
I do a "test-drive" to see if (1) other authors have already done this and (2) sufficient empirical studies are available on this topic to do an SR.
Results:
(1) Only one other "in-progress" SR is found in PROSPERO and it looks different from this one:
(2) Quick" scoping search of PubMed Clinical Queries for empirical studies on ivermection treatment of COVID-19. 418 results are found. This is a good number -- pick the "best" few and save them in MyNCBI as sentinel articles.
A good SR search question is specific and answerable.
Before you begin, search your SR question to see if a similar project is underway or has already been done.
Places to look:
Are there enough empirical studies (RCTs, etc.) available on my topic to do an SR? You will need a sufficient amount of existing research upon which to base your SR.
Do a trial (scoping) search using your PICO terms. If no/insufficient empirical studies are found, adjust your research question. If you find "on target" articles, save the best ones as sentinel articles.
Places to look:
non-PICO frameworks such as PEO (population-exposure-outcome) are used for topics that don't "fit" the PICO framework.
Here is an example:
Then, F. S., Luck, T., Luppa, M., Thinschmidt, M., Deckert, S., Nieuwenhuijsen, K., ... & Riedel-Heller, S. G. (2014). Systematic review of the effect of the psychosocial working environment on cognition and dementia. Occupational and environmental medicine, 71(5), 358-365.
Here is a list of commonly-used frameworks (Source: UNC at Chapel Hill)..